New target for post-stroke depressionPosted on November 13, 2013 by ECR Louisville in Blog, Stroke /Stroke Symptoms
Thank you Thomas Russell of Louisville, Kentucky for finding this article.
Friday 8 November 2013 – 12 am PST
MiRNAs likely play an important role in the occurrence and development of depression, and can be used as potential targets for treatment of depression.
Studies have shown that miR-137 expression is down regulated in the brain from depression patients with suicidal behavior.
Moreover, miR-137 expression is also down regulated in peripheral blood from stroke patients. However, it is not yet known if miRNAs are associated with post-stroke depression.
To test this, Dr. Lixia Zhao and colleagues from Shandong Provincial Hospital, China used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. Compared with controls, the researchers found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats.
Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels, and improved behavioral changes in post-stroke depression rats. Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A, regulating Grin2A expression in a neuronal cell line.
Grin2A gene overexpression in the brain of post-stroke depression rats, noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression.
Overall, these results, published in Neural Regeneration Research (Vol. 8, No. 26, 2013), show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA, thereby exerting an inhibitory effect on post-stroke depression. Our results offer a new therapeutic direction for post-stroke depression.
Article: ” miR-137, a new target for post-stroke depression?,” by Lixia Zhao1, 2, Huazi Li3, Ruiyou Guo2, Teng Ma2, Rongyao Hou2, Xiaowei Ma2, Yifeng Du1 (1 Department of Neurology, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China; 2 Department of Neurology, Haici Hospital Affiliated to Medical College of Qingdao University, Qingdao 266033, Shandong Province, China; 3 Department of Medical Imaging, Haici Hospital Affiliated to Medical College of Qingdao University, Qingdao 266033, Shandong Province, China)
Zhao LX, Li HZ, Guo RY, Ma T, Hou RY, Ma XW, Du YF. miR-137, a new target for post-stroke depression? Neural Regen Res. 2013;8(26):2441-2448.